Type 2 Diabetes Risk DNA Test
Is type 2 diabetes common in your family? Uncover your genetic risk today.
Measures:
- Identifies genetic variants related to glucose regulation, fat metabolism, and insulin sensitivity
- Higher risk of type 2 diabetes if both parents have the condition
Collection methods:
Buccal swabs
$349.00
- Discreet shipping
- Accredited lab
- Secure Online Results
- Highest accuracy
- Discreet
- Results in 1-3 business days
About the test
Genetic Risk Assessment for Type 2 Diabetes
Type 2 diabetes is a metabolic condition where the body struggles to maintain healthy blood sugar and insulin levels. While lifestyle factors like diet and exercise play a significant role, genetic predisposition can also significantly increase your risk of developing this disease, independent of your habits.
Insulin, a hormone produced by the pancreas, helps regulate glucose, the body’s main energy source. People with type 2 diabetes either don’t produce enough insulin or their bodies become resistant to its effects, leading to consistently high blood sugar levels.
This simple and painless mouth swab test reveals whether you carry genetic variations that may increase your risk of developing type 2 diabetes, allowing for proactive management of your health.
Genetic Profile
How Genetic Variations Affect Type 2 Diabetes Risk
Genetic variations can influence glucose and insulin regulation, our sensitivity to dietary fats, and the body’s response to insulin, all of which contribute to an increased risk of developing type 2 diabetes. By understanding these genetic factors, you can make proactive lifestyle changes to help reduce your risk of this life-altering condition.
| Gene(s) Tested | Effect |
| ACC2 | Reduced response to insulin |
| ADCY5 | Inhibited secretion of insulin |
| FABP2, FTO | Increased uptake of saturated fats |
| ADIPOQ, CRY2, FADS1, G6PC2, GLUT2, MTNR1B, PROX1, TCF7L2 | Increased fasting glucose levels |
| GCKR | Reduced fasting glucose levels |
| GCK, HNF4A | Reduced pancreatic beta cell function |
| GLIS3, IRS1, SLC30A8 | Disrupted insulin production/signalling/storage |
| SHBG | Increased sex hormone binding globulin |
| MADD | Impaired proinsulin-to-insulin conversion |
| SOD2 | Increased reactive oxygen species |
| HIF1A | Resistance to hypoxia |
- Genetic variation
- Family history of type 2 diabetes
- Obesity, especially abdominal fat
- Lack of physical activity
- Ethnicity (higher risk in African and American Indian populations)
- Prediabetes (elevated blood sugar levels)
- History of gestational diabetes
- Polycystic ovarian syndrome (PCOS)
-
Global Prevalence:
- More than 460 million people worldwide have diabetes, with 90% of those cases being type 2 diabetes.
- The global prevalence of type 2 diabetes is expected to rise to 700 million by 2045.
-
United States:
- 1 in 10 Americans have diabetes, with 90-95% of them having type 2 diabetes.
- 38% of U.S. adults are estimated to have prediabetes, with many unaware of their condition.
-
Age Factors:
- Type 2 diabetes is more common in adults over 45 years old, but increasing numbers of children and adolescents are being diagnosed due to rising obesity rates.
-
Risk by Ethnicity:
- African American, Hispanic, Native American, and Asian American populations are at higher risk for developing type 2 diabetes compared to Caucasians.
-
Complications:
- Type 2 diabetes is a leading cause of heart disease, kidney failure, stroke, and blindness.
- People with type 2 diabetes are 2-3 times more likely to experience a heart attack or stroke than those without the condition.
- Maintain a healthy weight – Lose 5-10% of body weight if overweight.
- Eat a balanced diet – Focus on fruits, veggies, whole grains, and lean proteins. Limit sugary foods.
- Exercise regularly – Aim for 150 minutes of moderate activity per week.
- Avoid long periods of sitting – Take breaks to move or stretch.
- Monitor blood sugar – Keep track if you’re at risk or have prediabetes.
- Quit smoking – Smoking increases diabetes risk.
- Limit alcohol – Drink in moderation.
- Manage stress – Use relaxation techniques like meditation or deep breathing.
- Get regular check-ups – Stay on top of your health if you have risk factors.
These simple lifestyle changes can help reduce the risk of type 2 diabetes.
Variants measured in this test
| Gene(s) Tested | Effect |
| ACC2 | Reduced response to insulin |
| ADCY5 | Inhibited secretion of insulin |
| FABP2, FTO | Increased uptake of saturated fats |
| ADIPOQ, CRY2, FADS1, G6PC2, GLUT2, MTNR1B, PROX1, TCF7L2 | Increased fasting glucose levels |
| GCKR | Reduced fasting glucose levels |
| GCK, HNF4A | Reduced pancreatic beta cell function |
| GLIS3, IRS1, SLC30A8 | Disrupted insulin production/signalling/storage |
| SHBG | Increased sex hormone binding globulin |
| MADD | Impaired proinsulin-to-insulin conversion |
| SOD2 | Increased reactive oxygen species |
| HIF1A | Resistance to hypoxia |
How many diabetes risk factors do you have?
- Genetic variation
- Family history of type 2 diabetes
- Obesity, especially abdominal fat
- Lack of physical activity
- Ethnicity (higher risk in African and American Indian populations)
- Prediabetes (elevated blood sugar levels)
- History of gestational diabetes
- Polycystic ovarian syndrome (PCOS)
Statistics on Type 2 Diabetes
-
Global Prevalence:
- More than 460 million people worldwide have diabetes, with 90% of those cases being type 2 diabetes.
- The global prevalence of type 2 diabetes is expected to rise to 700 million by 2045.
-
United States:
- 1 in 10 Americans have diabetes, with 90-95% of them having type 2 diabetes.
- 38% of U.S. adults are estimated to have prediabetes, with many unaware of their condition.
-
Age Factors:
- Type 2 diabetes is more common in adults over 45 years old, but increasing numbers of children and adolescents are being diagnosed due to rising obesity rates.
-
Risk by Ethnicity:
- African American, Hispanic, Native American, and Asian American populations are at higher risk for developing type 2 diabetes compared to Caucasians.
-
Complications:
- Type 2 diabetes is a leading cause of heart disease, kidney failure, stroke, and blindness.
- People with type 2 diabetes are 2-3 times more likely to experience a heart attack or stroke than those without the condition.
What can you do to prevent type 2 diabetes?
- Maintain a healthy weight – Lose 5-10% of body weight if overweight.
- Eat a balanced diet – Focus on fruits, veggies, whole grains, and lean proteins. Limit sugary foods.
- Exercise regularly – Aim for 150 minutes of moderate activity per week.
- Avoid long periods of sitting – Take breaks to move or stretch.
- Monitor blood sugar – Keep track if you’re at risk or have prediabetes.
- Quit smoking – Smoking increases diabetes risk.
- Limit alcohol – Drink in moderation.
- Manage stress – Use relaxation techniques like meditation or deep breathing.
- Get regular check-ups – Stay on top of your health if you have risk factors.
These simple lifestyle changes can help reduce the risk of type 2 diabetes.
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How Genetic Variations Affect Type 2 Diabetes Risk
Genetic variations can influence glucose and insulin regulation, our sensitivity to dietary fats, and the body’s response to insulin, all of which contribute to an increased risk of developing type 2 diabetes. By understanding these genetic factors, you can make proactive lifestyle changes to help reduce your risk of this life-altering condition.
