Celiac Disease DNA Test
Discover if you have genetic variants linked to a higher risk of celiac disease.
Measures:
- A negative result eliminates the risk of celiac disease for life
- Simple and painless mouth swab sample collection
- Every test is conducted twice for guaranteed accuracy
- No need to consume gluten before testing
- Suitable for individuals of all ages
Collection methods:
Buccal swabs
$249.00
- Discreet shipping
- Accredited lab
- Secure Online Results
- Highest accuracy
- Discreet
- Results in 1-3 business days
About the test
Are You Genetically Prone to Celiac Disease?
Celiac disease is an autoimmune condition triggered by consuming gluten, a protein found in wheat, rye, barley, malt, and brewer’s yeast. When individuals with celiac disease eat gluten, their immune system attacks the small intestine, leading to digestive issues, nutrient malabsorption, and long-term health complications.
Nearly all individuals with celiac disease carry specific genetic risk variants in their HLA genes. This DNA test analyzes your genetic profile to determine whether you have these celiac-associated variants. If your results are negative, you can confidently rule out celiac disease for life.
Genetic Profile
Genetic Testing for Celiac Disease
A simple DNA sequencing test can determine which variants of the HLA-DQA1 and HLA-DQB1 genes you carry. This test detects three key celiac-associated alleles—HLA-DQA105, HLA-DQB102, and HLA-DQB1*0302—which can combine to form the DQ2 and DQ8 heterodimers. The presence or absence of these alleles provides insight into your risk of gluten sensitivity and celiac disease.
If none of these genetic risk factors are detected, your likelihood of developing celiac disease is extremely low. Take this test to find out if you’re genetically predisposed and whether adopting a gluten-free diet is necessary for your health.
Celiac disease is an autoimmune disorder in which the immune system mistakenly attacks healthy cells. Individuals with this condition have an extreme sensitivity to gluten—a protein found in wheat, barley, and oats. When gluten is consumed, the immune system identifies it as a threat, triggering an inflammatory response. This reaction activates T-cells, leading to damage and destruction of the intestinal lining. As a result, nutrient absorption is impaired, potentially causing a range of digestive and systemic health issues.
Celiac disease can be difficult to diagnose, as symptoms vary widely and may be both digestive and non-digestive. Some individuals may not experience any noticeable digestive issues at all.
Common Digestive Symptoms:
- Bloating and excessive gas
- Constipation and/or diarrhea
- Changes in appetite
- Pale or bloody stools
- Nausea and vomiting
Other Possible Symptoms:
- Fatigue and frequent migraines
- Irritability and mood changes
- Depression and anxiety
- Muscle cramps and joint pain
- Delayed growth in children
- Mouth ulcers and skin rashes
- Hair thinning or loss
- Anemia
- Seizures
If you experience any of these symptoms, particularly after consuming gluten, genetic testing can help determine your risk of celiac disease.
| Patient Genotype (celiac-associated alleles present) | Celiac Disease Risk |
| DQ2 and DQ8 | 1:7 |
| DQ2 and Homozygous HLA-DQB1*02 | 1:10 |
| DQ2 and DQ2 | 1:10 |
| DQ8 and DQ8 | 1:12 |
| DQ8 and HLA-DQB1*02 | 1:24 |
| Homozygous HLA-DQB1*02 | 1:26 |
| DQ2 | 1:35 |
| DQ8 | 1:89 |
| Heterozygous HLA-DQB1*02 | 1:210 |
| HLA-DQA1*05 | 1:1842 |
| No HLA celiac-associated alleles detected | Not at risk of developing celiac disease, less than 1:2518 |
Understanding Celiac Disease
Celiac disease is an autoimmune disorder in which the immune system mistakenly attacks healthy cells. Individuals with this condition have an extreme sensitivity to gluten—a protein found in wheat, barley, and oats. When gluten is consumed, the immune system identifies it as a threat, triggering an inflammatory response. This reaction activates T-cells, leading to damage and destruction of the intestinal lining. As a result, nutrient absorption is impaired, potentially causing a range of digestive and systemic health issues.
Signs and Symptoms of Celiac Disease
Celiac disease can be difficult to diagnose, as symptoms vary widely and may be both digestive and non-digestive. Some individuals may not experience any noticeable digestive issues at all.
Common Digestive Symptoms:
- Bloating and excessive gas
- Constipation and/or diarrhea
- Changes in appetite
- Pale or bloody stools
- Nausea and vomiting
Other Possible Symptoms:
- Fatigue and frequent migraines
- Irritability and mood changes
- Depression and anxiety
- Muscle cramps and joint pain
- Delayed growth in children
- Mouth ulcers and skin rashes
- Hair thinning or loss
- Anemia
- Seizures
If you experience any of these symptoms, particularly after consuming gluten, genetic testing can help determine your risk of celiac disease.
The genetics details
| Patient Genotype (celiac-associated alleles present) | Celiac Disease Risk |
| DQ2 and DQ8 | 1:7 |
| DQ2 and Homozygous HLA-DQB1*02 | 1:10 |
| DQ2 and DQ2 | 1:10 |
| DQ8 and DQ8 | 1:12 |
| DQ8 and HLA-DQB1*02 | 1:24 |
| Homozygous HLA-DQB1*02 | 1:26 |
| DQ2 | 1:35 |
| DQ8 | 1:89 |
| Heterozygous HLA-DQB1*02 | 1:210 |
| HLA-DQA1*05 | 1:1842 |
| No HLA celiac-associated alleles detected | Not at risk of developing celiac disease, less than 1:2518 |
How it works
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Genetic Testing for Celiac Disease
A simple DNA sequencing test can determine which variants of the HLA-DQA1 and HLA-DQB1 genes you carry. This test detects three key celiac-associated alleles—HLA-DQA105, HLA-DQB102, and HLA-DQB1*0302—which can combine to form the DQ2 and DQ8 heterodimers. The presence or absence of these alleles provides insight into your risk of gluten sensitivity and celiac disease.
If none of these genetic risk factors are detected, your likelihood of developing celiac disease is extremely low. Take this test to find out if you’re genetically predisposed and whether adopting a gluten-free diet is necessary for your health.
